Founded in 2000 at Western Psychiatric Institute & Clinic, the Pittsburgh STOP Program targets low-income pregnant women to aid in decreasing or stopping prenatal smoking. An initial assessment is administered to gauge the woman's readiness to quit and to build an individualized treatment plan. Treatment options include self-help, brief counseling, and multi-session individual counseling for those who want to quit, stay quit, or decrease the amount of daily smoking. These treatment options include components of evidence-based interventions from the Public Health Service's Smoking Cessation Guidelines. Participants earn incentives for attending assessment and counseling sessions.

The goal is to reduce prenatal smoking, thereby improving the health of babies.

In a single-group pre-post evaluation study published in the American Journal of Health Promotion, of 856 pregnant women who were current smokers (93%) and recent quitters (7%), around 11% of smokers quit and 48% of pre-enrollment spontaneous quitters remained abstinent. Participants attended an average of 4.7 sessions, with a dropout rate of 5% after the first session.